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Efficacy of NZ2114, a Novel Plectasin-Derived Cationic Antimicrobial Peptide Antibiotic, in Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus ...

YQ Xiong, WA Hady, A Deslandes... - Antimicrobial Agents ..., 2011 - Am Soc Microbiol ABSTRACT Cationic antimicrobial peptides (CAPs) play important roles in host immune defenses. Plectasin is a defensin-like CAP isolated from the saprophytic fungus Pseudoplectania nigrella. NZ2114 is a novel variant of plectasin with potent activity ...

Leptin receptor-induced STAT3-independent signaling pathways are protective against atherosclerosis in a murine model of obesity and hyperlipidemia

W Luo, PF Bodary, Y Shen, KJ Wickenheiser... - Atherosclerosis, 2011 - Elsevier AIMS: Leptin is an adipocyte-derived hormone that has been shown to exert both beneficial metabolic effects and potentially adverse vascular effects in preclinical studies. The primary aim of this study was to determine the effects of leptin receptor signaling pathways on ...

... of new minimally invasive pacemaker lead explantation technique with conventional approach via median sternotomy in infective endocarditis in a presence of large ...

SKG Maier, M Rouw, T Zielinski, Y Cho... - ..., 2011 - Eur Heart Rhythm Assoc Abstract Introduction: ICD/CRT devices are in the infant stages of clinical acceptance concerning their ability for fluid monitoring in heart failure (HF) patients. In reality,> 30% of HF patients have a preserved LV-function and no indication for an ICD or CRT-device. We ...

Cardiac resynchronization therapy in heart failure: Doubts and certainties

M Ziacchi, M Biffi, E Cervi... - Cardiology and ..., 2012 - Abstract: Cardiac resynchronization therapy (CRT) is an effective and useful electrical treatment for appropriately selected heart failure patients with complete left bundle branch block, even for those with mild symptoms. It has been calculated that 3-12% of heart ...

Efficacy of three eight-week lifestyle interventions on weight loss and cardiovascular disease risk factors in obese adults

SA Walsh - 2012 - Abstract: There is little consensus on the most effective approach to promote weight loss and weight maintenance. Guided weight loss programs utilizing motivational interviewing (MI) have shown positive results for weight loss but they can be time consuming and ...
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