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Efficacy of NZ2114, a Novel Plectasin-Derived Cationic Antimicrobial Peptide Antibiotic, in Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus ...

YQ Xiong, WA Hady, A Deslandes... - Antimicrobial Agents ..., 2011 - Am Soc Microbiol ABSTRACT Cationic antimicrobial peptides (CAPs) play important roles in host immune defenses. Plectasin is a defensin-like CAP isolated from the saprophytic fungus Pseudoplectania nigrella. NZ2114 is a novel variant of plectasin with potent activity ...

Neural regulation of renal blood flow during experimental heart failure

SC Clayton - 2012 - Abstract: Excessive sympathetic tone is a hallmark of chronic heart failure (HF). Disease progression can be correlated with both plasma norepinephrine as well as renal function. Because the renal nerves and the renin-angiotensin II (Ang II) system are activated in HF, ...

The assessment of the cognitive regulation of emotions in bipolar I disorder using galvanic skin conductance and heart rate

F Corbalan - 2012 - Abstract: The cognitive regulation of negative emotions using a situational focused strategy require the activation of prefrontal and subcortical structures, in particular the dorsolateral prefrontal cortex (DLPFC) and the amygdala (Amy). These structures present structural ...

Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol–a clinical trial

E Kottenberg, M Thielmann... - Acta ..., 2012 - Wiley Online Library Background Remote ischemic preconditioning (RIPC) of the myocardium by limb ischemia/reperfusion may mitigate cardiac damage, but its interaction with the anesthetic regimen is unknown. We tested whether RIPC is associated with differential effects ...

Myocardial 123I‐metaiodobenzylguanidine Washout and Heart Rate Variability in Asymptomatic Subjects

S Simula, E Vanninen, A Hedman... - Annals of ..., 2012 - Wiley Online Library Background: Myocardial 123 I-metaiodobenzylguanidine (MIBG) kinetics reflect the integrity and function of cardiac presynaptic sympathetic nerve terminals. Heart rate variability (HRV) is an indicator of cardiac sympatho-vagal balance. However, the function of cardiac ...
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