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Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A/C Gene

W Wu, A Muchir, J Shan, G Bonne... - Circulation, 2011 - Am Heart Assoc Background Mutations in the lamin A/C gene, LMNA, can cause dilated cardiomyopathy. We have shown abnormal activation of the extracellular signal-regulated kinase (ERK) and the c-jun N-terminal kinase (JNK) branches of the mitogen-activated protein kinase signaling ...

Tranexamic Acid Reduces Blood Transfusions in Elderly Patients Undergoing Combined Aortic Valve and Coronary Artery Bypass Graft Surgery: A Randomized ...

G Greiff, R Stenseth, A Wahba, V Videm... - ... of Cardiothoracic and ..., 2011 - Elsevier To evaluate the effects of tranexamic acid on postoperative blood loss and transfusion requirements in elderly patients undergoing combined aortic valve replacement and coronary artery bypass graft surgery (CABG). ... A prospective, randomized, double-blinded, placebo-controlled, ...

C-Cure multicenter trial: lineage specified bone marrow derived cardiopoietic mesenchymal stem cells for treatment of ischemic cardiomyopathy

J Bartunek, W Wijns, D Dolatabadi... - Journal of the ..., 2011 - Am Coll Cardio Found... Coll. Cardiol. Miodrag Ostojic, Atta Behfar, Sophie Henry, Michal Tendera, and Scott Waldman Jozef Bartunek, William Wijns, Dariouch Dolatabadi, Marc Vanderheyden, Jo Dens, FOR TREATMENT OF ISCHEMIC CARDIOMYOPATHY MARROW DERIVED CARDIOPOIETIC ...

Expect the Unexpected: Sudden Cardiac Death in Dialysis Patients

RS Parekh - Clinical Journal of the American Society of ..., 2012 - Am Soc Nephrol Over the past decade, a number of clinical trials addressing dialysis dose and frequency and cardiovascular risk have revealed that sudden unexpected deaths are a common occurrence among incident and prevalent dialysis patients (1, 2). This high rate of out of ...

General and Disease-Specific Psychosocial Adjustment in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Patients with Implantable Cardioverter ...

CA James, C Tichnell, B Murray... - Circulation: ..., 2012 - Am Heart Assoc BackgroundArrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is characterized by frequent life-threatening ventricular arrhythmias diagnosed on average in the teens to mid-50's and commonly treated by implantable cardioverter defibrillators ( ...
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